Yes, if you operate a business from commercial premises within the City of Santa Ana you are required to secure a business license. Every business, including a temporary or itinerant business, operating from commercial premises within the City, is required to obtain a one-time Certificate of Occupancy ($134.24 for premises less than 5,000 sq. ft. in area | $499.36 for premises of 5,000 sq. ft. or more in area) for their commercial location and comply with all applicable provisions of the City of Santa Ana Municipal Code relating to Zoning and Building & Fire Safety. Businesses may apply and pay for their Certificate of Occupancy Inspections at the City of Santa Ana Planning Counter. For information on Certificate of Occupancy requirements, please contact the Planning Agency at (714) 647-5804 (Planning & Building Agency). A separate business license is required for each separate type of business conducted at the same location, and for each separate branch or business property location. A separate Certificate of Occupancy is required for each separate branch location.